人生长激素。55. 羧基末端纤溶酶片段肽类似物的合成及促生长活性。

Human somatotropin. 55. Synthesis and growth-promoting activity of peptide analogs of the carboxyl terminal plasmin fragment.

作者信息

Blake J, Li C H

出版信息

Int J Pept Protein Res. 1978 May;11(5):315-22.

Abstract

Three analogs of the carboxyl terminal plasmin fragment of human somatotropin, [Nle 170, Ala165, 182, 189]-human somatotropin-(145-191), [Nle170, Ala165, 182, 189]-human somatotropin-(140-191), and [Lys135,136, 138, Glu137, 139, Nle170, Ala165, 182, 189]-human somatotropin-(135-191) have been synthesized by the solid-phase method. The synthetic peptides were assayed for growth-promoting activity and their potency was found to be comparable to that of [S-carbamideomethylcysteine165,182, 189]-human somatotropin-(141-191) which was derived from the native hormone.

摘要

已通过固相法合成了人生长激素羧基末端纤溶酶片段的三种类似物，即[Nle 170, Ala165, 182, 189]-人生长激素-(145 - 191)、[Nle170, Ala165, 182, 189]-人生长激素-(140 - 191)和[Lys135,136, 138, Glu137, 139, Nle170, Ala165, 182, 189]-人生长激素-(135 - 191)。对合成肽进行了促生长活性测定，发现它们的效力与源自天然激素的[S-氨基甲酰甲基半胱氨酸165,182, 189]-人生长激素-(141 - 191)相当。

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