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[抗抑郁药的抗溃疡作用。II. 抗抑郁药卡赞、阿扎芬和OF-743与精氨酸联合应用对大鼠乙醇诱发胃黏膜损伤的影响]

[The antiulcer action of antidepressants. II. The effect of the antidepressants inkazan, azafen, and OF-743 in combination with arginine on ethanol-evoked damage to the gastric mucosa in rats].

作者信息

Natsvlishvili N A, Samonina G E, Ashmarin I P

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1991(7):52-7.

PMID:1782273
Abstract

Mucosal gastric damages in rats induced by intragastric ethanol introduction decreased considerably on the background of action of one of the antidepressants (asaphen, inkasan and OF-743) in combination with arginine. The combination OF-743 with arginine has the largest protective action, the least one--asaphen with arginine. A comparison of protective action of some antidepressants with action of antidepressants in combination with arginine revealed a tendency to more expressed antiulcerogenic effect in studied combinations.

摘要

通过胃内注入乙醇诱导的大鼠胃黏膜损伤,在其中一种抗抑郁药(阿沙芬、因卡桑和OF - 743)与精氨酸联合作用的背景下显著减轻。OF - 743与精氨酸的组合具有最大的保护作用,阿沙芬与精氨酸的组合保护作用最小。将一些抗抑郁药的保护作用与抗抑郁药与精氨酸联合使用的作用进行比较,发现在所研究的组合中存在抗溃疡作用更明显的趋势。

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