Brotman Daniel J, Golden Sherita H, Wittstein Ilan S
Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Lancet. 2007 Sep 22;370(9592):1089-100. doi: 10.1016/S0140-6736(07)61305-1.
Psychological stress elicits measurable changes in sympathetic-parasympathetic balance and the tone of the hypothalamic-pituitary-adrenal axis, which might negatively affect the cardiovascular system both acutely-by precipitating myocardial infarction, left-ventricular dysfunction, or dysrhythmia; and chronically-by accelerating the atherosclerotic process. We provide an overview of the association between stress and cardiovascular morbidity, discuss the mechanisms for this association, and address possible therapeutic implications.
心理压力会引起交感 - 副交感神经平衡以及下丘脑 - 垂体 - 肾上腺轴张力的可测量变化，这可能会对心血管系统产生负面影响，急性方面可引发心肌梗死、左心室功能障碍或心律失常；慢性方面可加速动脉粥样硬化进程。我们概述了压力与心血管疾病发病率之间的关联，讨论了这种关联的机制，并探讨了可能的治疗意义。
