Rossignol Serge, Barrière Grégory, Frigon Alain, Barthélemy Dorothy, Bouyer Laurent, Provencher Janyne, Leblond Hugues, Bernard Geneviève
Group and Centre for Research in Neurological Sciences, Multidisciplinary team in Locomotor Rehabilitation (CIHR), Department of Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada H3C 3J7.
Brain Res Rev. 2008 Jan;57(1):228-40. doi: 10.1016/j.brainresrev.2007.06.019. Epub 2007 Jul 31.
The present paper reviews aspects of locomotor sensorimotor interactions by focussing on work performed in spinal cats. We provide a brief overview of spinal locomotion and describe the effects of various types of sensory deprivations (e.g. rhizotomies, and lesions of muscle and cutaneous nerves) to highlight the spinal neuroplasticity necessary for adapting to sensory loss. Recent work on plastic interactions between reflex pathways that could be responsible for such plasticity, in particular changes in proprioceptive and cutaneous pathways that occur during locomotor training of spinal cats, is discussed. Finally, we describe how stimulation of some sensory inputs via various limb manipulations or intraspinal electrical stimulation can affect the expression of spinal locomotion. We conclude that sensory inputs are critical not only for locomotion but also that changes in the efficacy of sensory transmission and in the interactions between sensory pathways could participate in the normalization of locomotion after spinal and/or peripheral lesions.
本文通过聚焦于对脊髓猫所做的研究工作，回顾了运动感觉运动相互作用的各个方面。我们简要概述了脊髓运动，并描述了各种类型感觉剥夺（例如神经根切断术以及肌肉和皮神经损伤）的影响，以突出适应感觉丧失所必需的脊髓神经可塑性。讨论了近期关于可能导致这种可塑性的反射通路之间可塑性相互作用的研究工作，特别是在脊髓猫运动训练期间本体感觉和皮肤通路发生的变化。最后，我们描述了通过各种肢体操作或脊髓内电刺激对某些感觉输入的刺激如何影响脊髓运动的表达。我们得出结论，感觉输入不仅对运动至关重要，而且感觉传递效率的变化以及感觉通路之间的相互作用可能参与脊髓和/或周围损伤后运动的正常化。
