Batada Nizar N, Urrutia Araxi O, Hurst Laurence D
Department of Biology & Biochemistry, University of Bath, Bath, BA2 7AY, UK.
Trends Genet. 2007 Oct;23(10):480-4. doi: 10.1016/j.tig.2007.08.003. Epub 2007 Sep 5.
In diverse organisms, neighbouring genes in the genome tend to be positively coexpressed more than expected by chance. When the similarity of transcription regulation is controlled for, adjacent genes have much higher coexpression rates than unlinked genes, supporting a role for chromatin modelling. Consequently, many incidences of low-to-moderate level coexpression of linked genes might well be spurious rather than an indication of functional coordination. These results have implications for gene therapy and for understanding gene order evolution, suggesting that chromosomal proximity alone is adequate to achieve some level of coexpression.
在多种生物体中，基因组中相邻基因往往比随机预期的更倾向于正协同表达。当转录调控的相似性得到控制时，相邻基因的共表达率比非连锁基因高得多，这支持了染色质建模的作用。因此，许多低到中等水平的连锁基因共表达情况很可能是虚假的，而不是功能协调的指示。这些结果对基因治疗和理解基因顺序进化具有启示意义，表明仅染色体邻近性就足以实现一定程度的共表达。
