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二酰化1,10-二氮杂-18-冠-6作为钙离子荧光传感器的替代模板

Diacylated 1,10-diaza-18-crown-6 as an Alternative Template for Fluorescent Sensors of Calcium Ions.

作者信息

Smith Oscar G, Anene Jennifer C, Wheeler Simon

机构信息

Leicester School of Pharmacy De Montfort University The Gateway, Leicester UK.

出版信息

Anal Sci Adv. 2024 Nov 3;5(11-12):e202400034. doi: 10.1002/ansa.202400034. eCollection 2024 Dec.

DOI:10.1002/ansa.202400034
PMID:39660346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11627183/
Abstract

The performance of many known fluorescent sensors for Ca is pH-dependent. We set out to address this by preparing a novel calcium sensor based on diacylated 1,10-diaza-18-crown-6 and containing no basic centres. The sensor is sensitive to sub-millimolar levels of Ca and partially tolerant of an aqueous environment. However, it suffers from a lack of selectivity over some other divalent cations, and retained pH sensitivity in the acidic range. The relations between these properties and the sensor's structure are discussed.

摘要

许多已知的钙荧光传感器的性能都依赖于pH值。我们着手通过制备一种基于二酰化1,10-二氮杂-18-冠-6且不含碱性中心的新型钙传感器来解决这个问题。该传感器对亚毫摩尔浓度的钙敏感，并且对水性环境有一定耐受性。然而，它对其他一些二价阳离子缺乏选择性，并且在酸性范围内仍保留pH敏感性。本文讨论了这些性质与传感器结构之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/20735b5d843f/ANSA-5-e202400034-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/b875e60e4761/ANSA-5-e202400034-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/560d11ebe594/ANSA-5-e202400034-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/76c0f9323c07/ANSA-5-e202400034-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/13276fef0ef1/ANSA-5-e202400034-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/20735b5d843f/ANSA-5-e202400034-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/b875e60e4761/ANSA-5-e202400034-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/560d11ebe594/ANSA-5-e202400034-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/76c0f9323c07/ANSA-5-e202400034-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/13276fef0ef1/ANSA-5-e202400034-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd2/11627183/20735b5d843f/ANSA-5-e202400034-g003.jpg

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本文引用的文献

1
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Molecules. 2024 Jan 21;29(2):527. doi: 10.3390/molecules29020527.
2
Aggregation-induced Emission Active Naphthalimide Derived Schiff Base for Detecting Cu and Its Applications.用于检测铜的聚集诱导发光活性萘酰亚胺衍生席夫碱及其应用
J Fluoresc. 2024 Jan;34(1):359-366. doi: 10.1007/s10895-023-03287-z. Epub 2023 Jun 2.
3
A 1,8-naphthimide-based Fluorescent Probe for Analyzing DMF/HO Composition.一种用于分析N,N-二甲基甲酰胺/水组成的基于1,8-萘二甲酰亚胺的荧光探针。
J Fluoresc. 2024 Jan;34(1):169-178. doi: 10.1007/s10895-023-03251-x. Epub 2023 May 11.
4
Composition of the Solvation Shell of the Selected Cyclic Ethers (1,4-Dioxane, 12-Crown-4, 15-Crown-5 and 18-Crown-6) in a Mixture of Formamide with Water at Four Temperatures.所选环状醚（1,4-二氧六环、12-冠-4、15-冠-5 和 18-冠-6）在四种温度下的甲酰胺-水混合物中的溶剂化壳组成。
Molecules. 2023 Feb 26;28(5):2169. doi: 10.3390/molecules28052169.
5
The aqueous supramolecular chemistry of crown ethers.冠醚的水相超分子化学。
Front Chem. 2023 Jan 20;11:1119240. doi: 10.3389/fchem.2023.1119240. eCollection 2023.
6
"CinNapht" dyes: a new cinnoline/naphthalimide fused hybrid fluorophore. Synthesis, photo-physical study and use for bio-imaging.“CinNapht”染料：一种新型噌啉/萘酰亚胺稠合杂化荧光团。合成、光物理研究及其在生物成像中的应用。
RSC Adv. 2021 Sep 8;11(48):30088-30092. doi: 10.1039/d1ra05110e. eCollection 2021 Sep 6.
7
Synthesis, Biological Evaluation, and Molecular Modeling of Aza-Crown Ethers.氮杂冠醚的合成、生物评价及分子建模。
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8
Design and Applications of Small Molecular Probes for Calcium Detection.小分子钙探针的设计与应用。
Chem Asian J. 2019 Dec 13;14(24):4493-4505. doi: 10.1002/asia.201901149. Epub 2019 Oct 22.
9
The death of the Job plot, transparency, open science and online tools, uncertainty estimation methods and other developments in supramolecular chemistry data analysis.超分子化学数据分析中的Job图的消亡、透明度、开放科学与在线工具、不确定性估计方法及其他进展。
Chem Commun (Camb). 2016 Oct 25;52(87):12792-12805. doi: 10.1039/c6cc03888c.
10
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Chem Soc Rev. 2017 May 9;46(9):2437-2458. doi: 10.1039/c6cs00619a.