Cox-Foster Diana L, Conlan Sean, Holmes Edward C, Palacios Gustavo, Evans Jay D, Moran Nancy A, Quan Phenix-Lan, Briese Thomas, Hornig Mady, Geiser David M, Martinson Vince, vanEngelsdorp Dennis, Kalkstein Abby L, Drysdale Andrew, Hui Jeffrey, Zhai Junhui, Cui Liwang, Hutchison Stephen K, Simons Jan Fredrik, Egholm Michael, Pettis Jeffery S, Lipkin W Ian
Department of Entomology, Pennsylvania State University, University Park, PA 16802, USA.
Science. 2007 Oct 12;318(5848):283-7. doi: 10.1126/science.1146498. Epub 2007 Sep 6.
In colony collapse disorder (CCD), honey bee colonies inexplicably lose their workers. CCD has resulted in a loss of 50 to 90% of colonies in beekeeping operations across the United States. The observation that irradiated combs from affected colonies can be repopulated with naive bees suggests that infection may contribute to CCD. We used an unbiased metagenomic approach to survey microflora in CCD hives, normal hives, and imported royal jelly. Candidate pathogens were screened for significance of association with CCD by the examination of samples collected from several sites over a period of 3 years. One organism, Israeli acute paralysis virus of bees, was strongly correlated with CCD.
在蜂群崩溃失调（CCD）中，蜂群会莫名地失去工蜂。CCD已导致美国各地养蜂场50%至90%的蜂群损失。受影响蜂群的经辐照巢脾能用新蜂重新组建，这一观察结果表明感染可能与CCD有关。我们采用无偏差宏基因组学方法，对CCD蜂箱、正常蜂箱以及进口蜂王浆中的微生物群落进行了调查。通过检查在3年时间里从多个地点采集的样本，筛选出与CCD存在关联的重要候选病原体。一种生物，即蜜蜂以色列急性麻痹病毒，与CCD密切相关。
