Girolami A, Simioni P, Girolami B, Zanardi S
Institute of Medical Semeiotics, Fourth Chair of Internal Medicine, Padua, Italy.
Blood Coagul Fibrinolysis. 1991 Oct;2(5):673-8. doi: 10.1097/00001721-199110000-00015.
It is well established that pregnancy and puerperium, surgery and trauma may often trigger thrombotic events even in the normal population. On the other hand, patients with congenital deficiency of clotting inhibitors may develop spontaneous thrombotic episodes, although they become often symptomatic when one of the above-mentioned triggering factors is present. We found this to be true in 40 out of 81 symptomatic patients with congenital defects of coagulation inhibitors. In six (15%) of these cases medications (mainly oral contraceptives) triggered the thrombotic event. The incidence of pharmacological factors as a cause of thrombosis is commonly maintained to be low. This study indicates that this is not so and underlines the potential importance of drugs, particularly oral contraceptives, in the pathogenesis of thrombotic events in patients with congenital defects of clotting inhibitors.
众所周知，即使在正常人群中，妊娠和产褥期、手术及创伤也常常会引发血栓形成事件。另一方面，凝血抑制剂先天性缺乏的患者可能会发生自发性血栓形成发作，尽管当存在上述触发因素之一时他们常常会出现症状。我们发现，在81例有凝血抑制剂先天性缺陷的有症状患者中，有40例确实如此。在其中6例（15%）病例中，药物（主要是口服避孕药）引发了血栓形成事件。通常认为药物因素作为血栓形成原因的发生率较低。本研究表明情况并非如此，并强调了药物，尤其是口服避孕药，在凝血抑制剂先天性缺陷患者血栓形成事件发病机制中的潜在重要性。
