Parida Satya, Fleming Lucy, Gibson Debi, Hamblin Pip A, Grazioli Santina, Brocchi Emiliana, Paton David J
Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK.
J Vet Diagn Invest. 2007 Sep;19(5):539-44. doi: 10.1177/104063870701900513.
A panel of 36 sera has been assembled from experimental cattle that had been infected by inoculation or contact exposure with 4 serotypes of foot-and-mouth disease virus (FMDV) with or without prior vaccination. Virus replication and persistence had been characterized in all of the animals. The proportion of the sera scored positive by 5 tests for antibodies to the nonstructural proteins of FMDV varied, suggesting that the panel can discriminate between the sensitivity with which such tests are able to identify infected cattle. Use of this panel will help in assessment of new tests and quality control of existing methods.
从实验牛中收集了36份血清样本，这些实验牛通过接种或接触暴露感染了4种血清型的口蹄疫病毒（FMDV），部分牛有过预先接种疫苗的情况。已对所有动物的病毒复制和持续性进行了特征描述。通过5种检测口蹄疫病毒非结构蛋白抗体的试验，这些血清样本中呈阳性的比例各不相同，这表明该样本组能够区分这些检测方法识别感染牛的灵敏度。使用这个样本组将有助于评估新的检测方法以及现有方法的质量控制。
