Chatelain P, Carrascosa A, Bona G, Ferrandez-Longas A, Sippell W
Service d'Endocrinologie et Diabétologie Pédiatrique, Hôpital Debrousse, Lyon, France.
Horm Res. 2007;68(6):300-9. doi: 10.1159/000107935. Epub 2007 Sep 7.
Children born small for gestational age may demonstrate continued growth retardation, resulting in persistent short stature. In the majority of the cases, this is linked with abnormal growth hormone secretion and also abnormal insulin-like growth factor levels. This review discusses the treatment of such children with recombinant human growth hormone. It illustrates the importance of starting therapy early, the dose-dependent response, and the advantages of continuous therapy and describes safety considerations.
小于胎龄儿出生后可能会持续生长发育迟缓，导致身材持续矮小。在大多数情况下，这与生长激素分泌异常以及胰岛素样生长因子水平异常有关。本综述讨论了用重组人生长激素治疗此类儿童的情况。它阐述了早期开始治疗的重要性、剂量依赖性反应以及持续治疗的优势，并描述了安全注意事项。
