Monzote Lianet, Montalvo Ana Margarita, Scull Ramón, Miranda Migdalia, Abreu Juan
Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Ciudad de la Habana, Cuba.
Rev Inst Med Trop Sao Paulo. 2007 Jul-Aug;49(4):257-60. doi: 10.1590/s0036-46652007000400012.
To date, there are no vaccines against Leishmania, and chemotherapy remains the mainstay for the control of leishmaniasis. The drugs of choice used for leishmaniasis therapy are significantly toxic, expensive and with a growing frequency of refractory infections. Because of these limitations, a combination therapy is the better hope. This work demonstrates that the essential oil from Chenopodium ambrosioides shows a synergic activity after incubation in conjunction with pentamidine against promastigotes of Leishmania amazonensis. However, an indifferent effect has been found for combinations of meglumine antimoniate or amphotericin B and the essential oil.
迄今为止，尚无针对利什曼原虫的疫苗，化疗仍是控制利什曼病的主要手段。用于治疗利什曼病的首选药物毒性极大、价格昂贵，且难治性感染的发生率不断上升。鉴于这些局限性，联合疗法是更有希望的选择。这项研究表明，土荆芥精油与喷他脒联合孵育后，对亚马逊利什曼原虫前鞭毛体具有协同活性。然而，已发现葡甲胺锑酸盐或两性霉素B与该精油联合使用时效果不佳。
