Monzote Lianet, Montalvo Ana M, Almanonni Salah, Scull Ramón, Miranda Migdalia, Abreu Juan
Parasitology Department, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba.
Chemotherapy. 2006;52(3):130-6. doi: 10.1159/000092858. Epub 2006 Apr 21.
Current therapy against leishmaniasis is unsatisfactory. Efficacious and safe new drugs are needed. In this study, we show the leishmanicidal effect of an essential oil from Chenopodium ambrosioides against Leishmania amazonensis.
The tested product had a potent inhibitory action against promastigote and amastigote forms, with 50% effective dose values of 3.7 and 4.6 microg/ml, respectively. The essential oil showed a moderate toxicity on macrophages from BALB/c mice. An optimal dose of 30 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.
These studies revealed a potential source for the discovery of novel drugs to combat the leishmaniasis based on the traditional medicine.
目前治疗利什曼病的方法并不令人满意。需要有效且安全的新药。在本研究中，我们展示了土荆芥精油对亚马逊利什曼原虫的杀利什曼原虫作用。
受试产品对前鞭毛体和无鞭毛体形式具有强效抑制作用，半数有效剂量值分别为3.7和4.6微克/毫升。该精油对BALB/c小鼠的巨噬细胞显示出中等毒性。以30毫克/千克/天的最佳剂量通过腹腔途径对实验感染的BALB/c小鼠给药15天是有效的。
这些研究揭示了基于传统医学发现抗利什曼病新药的潜在来源。
