Alejandre-Alcázar Miguel A, Shalamanov Petar D, Amarie Oana V, Sevilla-Pérez Julia, Seeger Werner, Eickelberg Oliver, Morty Rory E
Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany.
Dev Dyn. 2007 Oct;236(10):2825-35. doi: 10.1002/dvdy.21293.
Bone morphogenetic proteins (BMPs) play important roles in early lung development. No study to date has addressed a role for BMP signaling in late lung development. We describe changes in the expression and localization of BMP receptors (Bmpr1a, Bmpr1b, and Bmpr2) and Smad (Smad1, Smad4, Smad5, and Smad8) intracellular signaling proteins during the saccular and alveolarization stages of late lung development. BMP signaling, assessed by Smad1/5 phosphorylation, nuclear translocation, and induction of id1, id2, and id3 gene expression, was evident throughout late lung development. Our data indicate that BMP signaling is active during late lung development, and points to roles for the BMP system in septal and vascular development, and in the homeostasis of the epithelial layer of large conducting airways in the mature lung.
骨形态发生蛋白（BMPs）在肺早期发育中发挥重要作用。迄今为止，尚无研究探讨BMP信号在肺后期发育中的作用。我们描述了在肺后期发育的囊状和肺泡化阶段，BMP受体（Bmpr1a、Bmpr1b和Bmpr2）以及Smad（Smad1、Smad4、Smad5和Smad8）细胞内信号蛋白的表达和定位变化。通过Smad1/5磷酸化、核转位以及id1、id2和id3基因表达的诱导来评估的BMP信号，在整个肺后期发育过程中均很明显。我们的数据表明，BMP信号在肺后期发育过程中是活跃的，这表明BMP系统在隔膜和血管发育以及成熟肺中大气道上皮层的稳态中发挥作用。
