Toma-Hirano Makiko, Namiki Sahori, Miyatake Shoichiro, Arai Ken-Ichi, Kamogawa-Schifter Yumiko
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Eur J Immunol. 2007 Oct;37(10):2707-14. doi: 10.1002/eji.200737173.
Ly49Q is expressed on peripheral mouse plasmacytoid dendritic cells (pDC). Immature Ly49Q-negative pDC precursors acquire Ly49Q in the bone marrow and then migrate into the periphery. While searching for molecules that regulate pDC maturation, we found that type I interferon (IFN) inhibited Ly49Q acquisition in vitro. Infections that induce type I IFN production by cells other than pDC (a condition mimicked by poly(I:C) injection in vivo) increase the prevalence of Ly49Q(-) pDC in the bone marrow and peripheral lymphoid organs in wild-type but not IFN-alpha/beta receptor knockout BALB/c mice. Moreover, in vivo exposure to type I IFN causes some Ly49Q(-), but not Ly49Q(+), pDC to convert to conventional DC, defined as B220(-) CD11c(+) CD11b(+) cells. These data suggest that type I IFN regulates pDC development and affects their distribution in the body.
Ly49Q在外周小鼠浆细胞样树突状细胞（pDC）上表达。未成熟的Ly49Q阴性pDC前体在骨髓中获得Ly49Q，然后迁移至外周。在寻找调节pDC成熟的分子时，我们发现I型干扰素（IFN）在体外抑制Ly49Q的获得。由pDC以外的细胞诱导I型IFN产生的感染（体内注射聚肌胞苷酸（poly(I:C)）可模拟这种情况）会增加野生型而非IFN-α/β受体敲除的BALB/c小鼠骨髓和外周淋巴器官中Ly49Q(-) pDC的比例。此外，体内暴露于I型IFN会使一些Ly49Q(-)而非Ly49Q(+) pDC转变为传统树突状细胞，即定义为B220(-) CD11c(+) CD11b(+)的细胞。这些数据表明I型IFN调节pDC的发育并影响其在体内的分布。
