Bogra Jaishri, Gangoo R, Pandey V C, Srivastava Pratima
Department of Anaesthesiology, King George's Medical College, Lucknow 226003.
J Indian Med Assoc. 2007 Mar;105(3):128-9, 132.
Reactive oxygen species are a part of the normal physiology of the biological system but their subsequent defence undergoes alteration during diseased conditions. Administration of anaesthesia for surgery may also alter the formation of reactive oxygen species. The present work deals with the comparative status of oxidative stress (lipid peroxidation) and anti-oxidant defence markers (superoxide dismutase and catalase) in blood in 3 groups of 15 patients each receiving halothane, relaxant vecuronium and spinal form of anaesthesia with lignocaine 5% heavy. The results obtained depict that the formation of malonyl dialdehyde as well as decrease in superoxide dismutase and catalase activities was highest in spinal anaesthesia followed by halothane and then relaxant group. Therefore, it seems important to consider the pre-operative anti-oxidant status while administering anaesthesia to such patients in order to provide biologically safe anaesthesia.
活性氧是生物系统正常生理的一部分，但在患病状态下其后续防御会发生改变。手术麻醉的实施也可能改变活性氧的形成。本研究探讨了三组各15例患者血液中氧化应激（脂质过氧化）和抗氧化防御标志物（超氧化物歧化酶和过氧化氢酶）的比较状况，这三组患者分别接受氟烷、肌松药维库溴铵以及5%重比重利多卡因的脊髓麻醉。所得结果表明，脊髓麻醉组丙二醛的形成以及超氧化物歧化酶和过氧化氢酶活性的降低最为显著，其次是氟烷组，然后是肌松药组。因此，在给这类患者实施麻醉时，考虑术前抗氧化状态似乎很重要，以便提供生物安全的麻醉。
