Nikolaidis Michalis G, Jamurtas Athanasios Z
Institute of Human Performance and Rehabilitation, Centre for Research and Technology-Thessaly, Trikala, Greece.
Arch Biochem Biophys. 2009 Oct 15;490(2):77-84. doi: 10.1016/j.abb.2009.08.015. Epub 2009 Aug 25.
The exact origin of reactive species and oxidative damage detected in blood is largely unknown. Blood interacts with all organs and tissues and, consequently, with many possible sources of reactive species. In addition, a multitude of oxidizable substrates are already in blood. A muscle-centric approach is frequently adopted to explain reactive species generation, which obscures the possibility that sources of reactive species and oxidative damage other than skeletal muscle may be also at work during exercise. Plasma and blood cells can autonomously produce significant amounts of reactive species at rest and during exercise. The major reactive species generators located in blood during exercise may be erythrocytes (mainly due to their quantity) and leukocytes (mainly due to their drastic activation during exercise). Therefore, it is plausible to assume that oxidative stress/damage measured frequently in blood after exercise or any other experimental intervention derives, at least in part, from the blood.
血液中检测到的活性物质和氧化损伤的确切来源在很大程度上尚不清楚。血液与所有器官和组织相互作用，因此，与许多可能的活性物质来源相互作用。此外，血液中已经存在大量可氧化的底物。人们经常采用以肌肉为中心的方法来解释活性物质的产生，这掩盖了在运动过程中除骨骼肌之外的活性物质和氧化损伤来源也可能起作用的可能性。血浆和血细胞在静息和运动期间可以自主产生大量活性物质。运动期间血液中主要的活性物质产生者可能是红细胞（主要因其数量）和白细胞（主要因其在运动期间的剧烈激活）。因此，可以合理地假设，运动后或任何其他实验干预后在血液中频繁测量到的氧化应激/损伤至少部分源自血液。
