Tanghetti Emil
Department of Dermatology, University of California, Davis, USA.
Cutis. 2007 Jul;80(1 Suppl):5-9.
Bacterial resistance to antibiotics began to emerge soon after their introduction. Beginning in the 1970s, Propionibacterium acnes also began to show decreased sensitivity to the antibiotics typically used in acne management. Clinically, this trend has translated to decreased efficacy and even nonresponse to therapy. A variety of recommendations regarding optimum use of antibiotics in acne management have been developed to preserve the utility of these drugs. Most important is the use of combination therapy with benzoyl peroxide (BPO) to help minimize the development of resistance. Retinoids also are recommended in acne therapeutic regimens because these agents are active against most acne pathogenetic mechanisms, but they have no apparent activity preventing antibiotic resistance when used in combination with a topical antibiotic.
抗生素问世后不久，细菌就开始出现耐药性。从20世纪70年代开始，痤疮丙酸杆菌对痤疮治疗中常用的抗生素也开始表现出敏感性降低。在临床上，这种趋势已转化为疗效降低甚至治疗无反应。已经制定了关于痤疮治疗中抗生素最佳使用的各种建议，以保持这些药物的效用。最重要的是使用过氧化苯甲酰（BPO）联合治疗，以帮助尽量减少耐药性的产生。维甲酸类药物也被推荐用于痤疮治疗方案中，因为这些药物对大多数痤疮发病机制都有作用，但与外用抗生素联合使用时，它们在预防抗生素耐药性方面没有明显作用。
