Tanghetti Emil
Department of Dermatology, University of California, Davis, California, USA.
Cutis. 2008 Nov;82(5 Suppl):5-11.
Since its first use in dermatology last century, benzoyl peroxide (BPO) has undergone a number of reformulations, each enhancing its efficacy, tolerability, or both. Benzoyl peroxide can be used as monotherapy or in combination with oral or topical antibiotics or topical retinoids. Its antimicrobial activity is based on the generation of highly reactive oxygen radicals, a physicochemical effect to which Propionibacterium acnes has not developed resistance. In addition to its nonspecific antimicrobial activity, BPO has keratolytic, comedolytic, and anti-inflammatory activity in acne. Benzoyl peroxide can be added to antibiotic regimens to help maintain bacterial sensitivity to the antibiotic. Additive or synergistic effects of BPO-antibiotic combinations have been demonstrated. Fixed combinations of BPO with either antibiotics or a retinoid recently have become available and may improve compliance. New moisturizing vehicles and stabilized BPO formulations also have added to tolerability and convenience. Benzoyl peroxide may have underappreciated potential to treat noninflammatory acne as monotherapy or in combination with a topical retinoid, an important antibiotic-sparing strategy.
自上世纪首次用于皮肤科以来，过氧化苯甲酰（BPO）经历了多次配方改革，每次改革都提高了其疗效、耐受性或两者兼具。过氧化苯甲酰可作为单一疗法使用，或与口服或外用抗生素或外用维甲酸联合使用。其抗菌活性基于高活性氧自由基的产生，这是一种痤疮丙酸杆菌尚未产生耐药性的物理化学效应。除了其非特异性抗菌活性外，BPO在痤疮中还具有角质溶解、粉刺溶解和抗炎活性。过氧化苯甲酰可添加到抗生素治疗方案中，以帮助维持细菌对抗生素的敏感性。已证明BPO与抗生素组合具有相加或协同作用。BPO与抗生素或维甲酸的固定组合最近已上市，可能会提高依从性。新的保湿载体和稳定的BPO制剂也提高了耐受性和便利性。过氧化苯甲酰作为单一疗法或与外用维甲酸联合使用，在治疗非炎性痤疮方面可能具有未被充分认识的潜力，这是一种重要的抗生素节约策略。
