Li Shun-Li, Lan Ya-Qian, Ma Jian-Fang, Yang Jin, Wang Xiao-Hong, Su Zhong-Min
Key Lab of Polyoxometalate Science, Department of Chemistry, Northeast Normal University, Changchun 130024, People's Republic of China.
Inorg Chem. 2007 Oct 1;46(20):8283-90. doi: 10.1021/ic700913m. Epub 2007 Sep 8.
Five organic-inorganic hybrid compounds, namely, [Co2(fcz)4(H2O)4][beta-Mo8O26].5H2O (1), [Ni2(fcz)4(H2O)4][beta-Mo8O26].5H2O (2), [Zn2(fcz)4(beta-Mo8O26)].4H2O (3), [Cu2(fcz)4(beta-Mo8O26)].4H2O (4), and [Ag4(fcz)4(beta-Mo8O26)] (5), where fcz is fluconazole [2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol], were synthesized under hydrothermal conditions, and crystal structures of 1-5 have been determined by X-ray diffraction. In compounds 1 and 2, metal cations are linked by fluconazole ligands to form hinged chain structures and [beta-Mo8O26]4- anions act as counterions. In compound 3, Zn(II) cations are bridged by fluconazole ligands to form 2D (4,4) networks, and each pair of these networks is linked by [beta-Mo8O26]4- anions to form a sandwich double-layer structure. In compound 4, Cu(II) cations are bridged by fluconazole ligands to form 2D (4,4) networks, and these networks are connected by [beta-Mo8O26]4- anions to form a 3D framework. In compound 5, AgI cations and [Ag2]2+ units are bridged by fluconazole ligands to form 2D Ag-fcz layers, and these layers are further connected by [beta-Mo8O26]4- anions to form a complicated 3D structure with the topology of (7(2).8(1))2(7(3).8(3))(7(2).8(11).10(1).12(1))2. Thermogravimetric analyses for these compounds are also discussed in detail. The complexes exhibit antitumor activity in vitro, as shown by MTT experiments.
合成了五种有机 - 无机杂化化合物，即[Co2(fcz)4(H2O)4][β - Mo8O26]·5H2O (1)、[Ni2(fcz)4(H2O)4][β - Mo8O26]·5H2O (2)、[Zn2(fcz)4(β - Mo8O26)]·4H2O (3)、[Cu2(fcz)4(β - Mo8O26)]·4H2O (4)和[Ag4(fcz)4(β - Mo8O26)] (5)，其中fcz为氟康唑[2-(2,4 - 二氟苯基)-1,3 - 二(1H - 1,2,4 - 三唑 - 1 -基)丙 - 2 -醇]，这些化合物是在水热条件下合成的，并且通过X射线衍射测定了1 - 5的晶体结构。在化合物1和2中，金属阳离子通过氟康唑配体连接形成铰链链结构，[β - Mo8O26]4 - 阴离子作为抗衡离子。在化合物3中，Zn(II)阳离子由氟康唑配体桥联形成二维(4,4)网络，并且这些网络中的每一对通过[β - Mo8O26]4 - 阴离子连接形成夹心双层结构。在化合物4中，Cu(II)阳离子由氟康唑配体桥联形成二维(4,4)网络，并且这些网络通过[β - Mo8O26]4 - 阴离子连接形成三维骨架。在化合物5中，AgI阳离子和[Ag2]2 + 单元由氟康唑配体桥联形成二维Ag - fcz层，并且这些层进一步通过[β - Mo8O26]4 - 阴离子连接形成具有(7(2).8(1))2(7(3).8(3))(7(2).8(11).10(1).12(1))2拓扑结构的复杂三维结构。还详细讨论了这些化合物的热重分析。如MTT实验所示，这些配合物在体外表现出抗肿瘤活性。
