Cortat Youri, Zobi Fabio
Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland.
Pharmaceutics. 2023 Sep 28;15(10):2398. doi: 10.3390/pharmaceutics15102398.
Coordination compounds featuring one or more antifungal azole (AA) ligands constitute an interesting family of candidate molecules, given their medicinal polyvalence and the viability of drug complexation as a strategy to improve and repurpose available medications. This review reports the work performed in the field of coordination derivatives of AAs synthesized for medical purposes by discussing the corresponding publications and emphasizing the most promising compounds discovered so far. The resulting overview highlights the efficiency of AAs and their metallic species, as well as the potential still lying in this research area.
含有一种或多种抗真菌唑（AA）配体的配位化合物构成了一类有趣的候选分子家族，这是由于它们具有药物多价性以及药物络合作为改善和重新利用现有药物的策略的可行性。本综述通过讨论相应的出版物并强调迄今为止发现的最有前景的化合物，报告了在为医学目的合成的AA配位衍生物领域所开展的工作。所得概述突出了AA及其金属物种的有效性，以及该研究领域仍存在的潜力。
