Clayton R H, Panfilov A V
Department of Computer Science, University of Sheffield, Regent Court, 211 Portobello Street, Sheffield, S1 4DP, UK.
Prog Biophys Mol Biol. 2008 Jan-Apr;96(1-3):19-43. doi: 10.1016/j.pbiomolbio.2007.07.004. Epub 2007 Aug 1.
One of the most recent trends in cardiac electrophysiology is the development of integrative anatomically accurate models of the heart, which include description of cardiac activity from sub-cellular and cellular level to the level of the whole organ. In order to construct this type of model, a researcher needs to collect a wide range of information from books and journal articles on various aspects of biology, physiology, electrophysiology, numerical mathematics and computer programming. The aim of this methodological article is to survey recent developments in integrative modelling of electrical activity in the ventricles of the heart, and to provide a practical guide to the resources and tools that are available for work in this exciting and challenging area.
心脏电生理学领域的最新趋势之一是构建精确的心脏综合解剖模型，该模型涵盖了从亚细胞和细胞水平到整个器官水平的心脏活动描述。为了构建此类模型，研究人员需要从书籍和期刊文章中收集有关生物学、生理学、电生理学、数值数学和计算机编程等各个方面的广泛信息。这篇方法学文章的目的是综述心脏心室电活动综合建模的最新进展，并为在这个令人兴奋且具有挑战性的领域开展工作提供实用的资源和工具指南。
