Suppr超能文献

正常B细胞记忆反应的发展需要IgM介导的信号传导。

IgM-mediated signaling is required for the development of a normal B cell memory response.

作者信息

Guo Linjie, Zhang Xuejun, Zheng Biao, Han Shuhua

机构信息

Department of Immunology, Baylor College of Medicine, One Baylor Plaza, M929 Houston, TX 77030, USA.

出版信息

Mol Immunol. 2008 Feb;45(4):1071-7. doi: 10.1016/j.molimm.2007.07.034. Epub 2007 Sep 6.

Abstract

Mature B cells co-express both IgM and IgD types of antigen receptors before activation. Our earlier work has shown that the co-expression of IgD and IgM plays an important role in regulating the composition of antibody repertoire during a primary immune response. However, the roles of these two B cell receptors in the development of B cell memory responses remain unclear. The present study shows that during the secondary immune response to (4-hydroxy-3-nitrophenyl)acetyl (NP), IgM-/- mice secreted significant amount of NP-specific IgD antibodies. The kinetics of antigen-specific IgD antibodies produced in IgM-/- mice was similar to that of IgM antibodies in wild type mice during the secondary response. However, the production of antigen-specific class-switched antibodies in IgM-/- mice was significantly reduced compared to that in wild type mice, particularly at the early phase of the memory response. In addition, germinal center (GC) reaction was significantly diminished in IgM-/- mice after secondary challenge with soluble antigen. Nevertheless, affinity maturation of antibodies appears largely intact in IgM-/- mice during memory response. Thus, our studies demonstrate that IgM-mediated signaling plays an important role in the development of efficient B cell memory responses.

摘要

成熟B细胞在激活前共表达IgM和IgD两种类型的抗原受体。我们早期的研究表明,IgD和IgM的共表达在初次免疫应答期间调节抗体库的组成中发挥重要作用。然而,这两种B细胞受体在B细胞记忆应答发展中的作用仍不清楚。本研究表明,在对(4-羟基-3-硝基苯基)乙酰基(NP)的二次免疫应答期间,IgM基因敲除小鼠分泌大量NP特异性IgD抗体。在二次应答期间,IgM基因敲除小鼠产生的抗原特异性IgD抗体的动力学与野生型小鼠中IgM抗体的动力学相似。然而,与野生型小鼠相比,IgM基因敲除小鼠中抗原特异性类别转换抗体的产生显著减少,特别是在记忆应答的早期阶段。此外,在用可溶性抗原二次攻击后,IgM基因敲除小鼠中的生发中心(GC)反应显著减弱。然而,在记忆应答期间,IgM基因敲除小鼠中抗体的亲和力成熟似乎基本完整。因此,我们的研究表明,IgM介导的信号传导在有效的B细胞记忆应答的发展中发挥重要作用。

相似文献

1
IgM-mediated signaling is required for the development of a normal B cell memory response.
Mol Immunol. 2008 Feb;45(4):1071-7. doi: 10.1016/j.molimm.2007.07.034. Epub 2007 Sep 6.
2
IgD+IgM- B cells mount immune responses that exhibit altered antibody repertoire.
Eur J Immunol. 2004 Mar;34(3):661-668. doi: 10.1002/eji.200324493.
6
The riddle of the dual expression of IgM and IgD.
Immunology. 2006 Aug;118(4):429-37. doi: 10.1111/j.1365-2567.2006.02386.x.
8
Primary Immune Responses and Affinity Maturation Are Controlled by IgD.
Front Immunol. 2021 Aug 9;12:709240. doi: 10.3389/fimmu.2021.709240. eCollection 2021.

引用本文的文献

2
IgM, Fc mu Rs, and malarial immune evasion.
J Immunol. 2010 May 1;184(9):4597-603. doi: 10.4049/jimmunol.1000203.

本文引用的文献

1
IgD+IgM- B cells mount immune responses that exhibit altered antibody repertoire.
Eur J Immunol. 2004 Mar;34(3):661-668. doi: 10.1002/eji.200324493.
6
IgD can largely substitute for loss of IgM function in B cells.
Nature. 1998 Jun 25;393(6687):797-801. doi: 10.1038/31716.
8
9
In situ studies of the germinal center reaction.
Adv Immunol. 1995;60:267-88. doi: 10.1016/s0065-2776(08)60587-8.
10
Immunological memory.
Annu Rev Immunol. 1993;11:49-77. doi: 10.1146/annurev.iy.11.040193.000405.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验