Riviere Jim E
Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
Vet J. 2007 Nov;174(3):462-71. doi: 10.1016/j.tvjl.2007.06.022. Epub 2007 Sep 6.
The purpose of this article is to make an educated guess as to what veterinary pharmacology will look like in two decades. By examining the past, it is evident that change is incremental unless a transforming discovery occurs. In the last few decades, such events have dramatically changed medicine and pharmacology, however they have not percolated through the system to the effect that novel drugs have replaced our traditional armamentarium. The effect of six transforming technologies (continued advances in computer technology, microfluidics, nanotechnology, high-throughput screening, control and targeted drug delivery, pharmacogenomics) on veterinary therapeutics is examined. These should lead toward more efficacious and safer drugs across most therapeutic classes due to both increases in our knowledge base as well as more efficient drug development. Shorter term improvements in drug delivery should be seen. Although this growth in technology would portend major advances over the next few decades, economic and regulatory constraints must still be overcome for these new drugs or therapeutic approaches to become common practice.
本文旨在对未来二十年兽医药理学的发展进行合理推测。回顾过去，很明显，除非有变革性的发现，变化是渐进的。在过去几十年里，这类事件极大地改变了医学和药理学，但它们尚未完全渗透到整个体系，以至于新型药物取代了我们传统的药物库。本文探讨了六种变革性技术（计算机技术、微流体技术、纳米技术、高通量筛选、可控靶向给药、药物基因组学的持续进步）对兽医治疗学的影响。由于我们知识库的增加以及更高效的药物开发，这些技术应能在大多数治疗类别中带来更有效、更安全的药物。短期内应能看到药物递送方面的改进。尽管技术的这种发展预示着未来几十年将取得重大进展，但要使这些新药或治疗方法成为常规做法，仍必须克服经济和监管方面的限制。
