Riviere Jim E
Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA.
Handb Exp Pharmacol. 2010(199):191-210. doi: 10.1007/978-3-642-10324-7_8.
The purpose of this contribution is to review new technologies and make an educated prediction as to how they will impact veterinary pharmacology over the coming decades. By examining past developments, it becomes evident that change is incremental and predictable unless either a transforming discovery or a change in societal behaviour occurs. In the last century, both discoveries and behaviours have dramatically changed medicine, pharmacology and therapeutics. In this chapter, the potential effects of six transforming technologies on veterinary therapeutics are examined: continued advances in computer technology, microfluidics, nanotechnology, high-throughput screening, control and targeted drug delivery and pharmacogenomics. These should lead to the more efficacious and safer use of existing medicants, and the development of novel drugs across most therapeutic classes through increases in our knowledge base, as well as more efficient drug development. Although this growth in technology portends major advances over the next few decades, economic and regulatory constraints must still be overcome for these new drugs or therapeutic approaches to become common practise.
本文的目的是回顾新技术，并就是否会在未来几十年对兽医药理学产生影响做出有根据的预测。通过审视过去的发展可以明显看出，除非出现变革性的发现或社会行为的变化，否则变革是渐进且可预测的。在上个世纪，发现和行为都极大地改变了医学、药理学和治疗学。在本章中，将探讨六种变革性技术对兽医治疗学的潜在影响：计算机技术的持续进步、微流体技术、纳米技术、高通量筛选、可控和靶向药物递送以及药物基因组学。这些技术应能使现有药物的使用更加有效和安全，并通过增加我们的知识库以及更高效的药物开发，推动大多数治疗类别的新药研发。尽管技术的这种发展预示着未来几十年将取得重大进展，但要使这些新药或治疗方法成为常规做法，仍必须克服经济和监管方面的限制。
