Jamieson Denise J, Cohen Mardge H, Maupin Robert, Nesheim Steven, Danner Susan P, Lampe Margaret A, O'Sullivan Mary Jo, Webber Mayris P, Wiener Jeffrey, Carter Rosalind J, Rivero Yvette, Fowler Mary Glenn, Bulterys Marc
Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.
Am J Obstet Gynecol. 2007 Sep;197(3 Suppl):S72-82. doi: 10.1016/j.ajog.2007.03.067.
The objective of the study was to evaluate the feasibility, acceptability, and accuracy of rapid human immunodeficiency virus (HIV) testing during labor. The Mother-Infant Rapid Intervention at Delivery (MIRIAD) study was a prospective, multicenter study that offered voluntary, rapid HIV testing to women with undocumented HIV status at 17 hospitals in 6 cities. Of 12,481 eligible women, 74% were approached for participation and 85.5% of those approached accepted rapid HIV testing. Among 7753 women tested, MIRIAD identified 52 (0.7%) HIV-infected women. The time between obtaining the blood sample for the rapid test and reporting the results to the health care provider was shorter for hospitals utilizing point-of-care testing than in hospitals utilizing laboratory-based testing (30 minutes vs 68 minutes; P < .0001), and point-of-care testing strategies were 14 times more likely to have a short turnaround as laboratory testing strategies. Routine rapid testing during labor provides a feasible, acceptable, and accurate way to identify HIV-infected women before delivery.
该研究的目的是评估分娩期间快速检测人类免疫缺陷病毒（HIV）的可行性、可接受性和准确性。分娩时母婴快速干预（MIRIAD）研究是一项前瞻性多中心研究，在6个城市的17家医院为HIV感染状况不明的女性提供自愿快速HIV检测。在12481名符合条件的女性中，74%的人被邀请参与，其中85.5%的人接受了快速HIV检测。在7753名接受检测的女性中，MIRIAD研究识别出52名（0.7%）HIV感染女性。与采用基于实验室检测的医院相比，采用即时检测的医院从采集快速检测血样到向医疗服务提供者报告结果的时间更短（30分钟对68分钟；P < .0001），即时检测策略的周转时间短于实验室检测策略的可能性高14倍。分娩期间进行常规快速检测为在分娩前识别HIV感染女性提供了一种可行、可接受且准确的方法。
