Yasui Toshiyuki, Tomita Junko, Miyatani Yuka, Yamada Masayo, Uemura Hirokazu, Irahara Minoru, Arai Makoto, Kojimahara Noriko, Okabe Ryugo, Ishii Yasutomo, Tashiro Shin-ichi, Sato Hiroshi
Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.
Clin Chim Acta. 2007 Nov-Dec;386(1-2):69-75. doi: 10.1016/j.cca.2007.08.001. Epub 2007 Aug 14.
Changes with aging in serum gonadal hormones, sex hormone-binding globulin (SHBG) and adiponectin, which are involved in insulin resistance and metabolic syndrome, are different in men and women. We examined the relationships of serum adiponectin concentrations with serum concentrations of hormones and SHBG in men and women.
One hundred fifty-four men and 180 women aged from 50 to 85 years were included in the cross-sectional study. Serum concentrations of testosterone, estradiol, dehydroepiandrosterone-sulfate, SHBG and adiponectin were measured in men and women.
Serum adiponectin concentration showed a significant positive correlation with serum SHBG concentration in men and women (r=0.404, p<0.0001 and r=0.348, p<0.0001, respectively). Multiple regression analysis also showed that SHBG was the significant predictor for adiponectin in men and women. Serum adiponectin concentration in men showed a significant positive correlation with total testosterone concentration, but that in women was not significantly correlated with total testosterone concentration. Both adiponectin and SHBG concentrations in men (r=-0.222, p=0.0051 and r=-0.334, p<0.0001, respectively) and women (r=-0.281, p=0.0014 and r=-0.251, p=0.0048, respectively) showed significant negative correlations with the homeostasis model assessment (HOMA) index.
Correlations between adiponectin and SHBG were significantly positive in both men and women, and both adiponectin and SHBG might be involved in insulin resistance in both sexes.
血清性腺激素、性激素结合球蛋白（SHBG）和脂联素随年龄的变化在男性和女性中有所不同，这些激素与胰岛素抵抗和代谢综合征有关。我们研究了男性和女性血清脂联素浓度与激素及SHBG血清浓度之间的关系。
这项横断面研究纳入了154名年龄在50至85岁之间的男性和180名女性。测量了男性和女性血清中的睾酮、雌二醇、硫酸脱氢表雄酮、SHBG和脂联素浓度。
男性和女性血清脂联素浓度与血清SHBG浓度均呈显著正相关（分别为r = 0.404，p < 0.0001和r = 0.348，p < 0.0001）。多元回归分析还表明，SHBG是男性和女性脂联素的显著预测因子。男性血清脂联素浓度与总睾酮浓度呈显著正相关，但女性血清脂联素浓度与总睾酮浓度无显著相关性。男性（分别为r = -0.222，p = 0.0051和r = -0.334，p < 0.0001）和女性（分别为r = -0.281，p = 0.0014和r = -0.251，p = 0.0048）的脂联素和SHBG浓度与稳态模型评估（HOMA）指数均呈显著负相关。
脂联素与SHBG之间的相关性在男性和女性中均显著为正，脂联素和SHBG可能均参与了两性的胰岛素抵抗。
