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乳腺癌幸存者的身体成分以及基质金属蛋白酶-9、脂联素和AMP激活的蛋白激酶的血清水平

Body composition and serum levels of matrix metalloproteinase-9, adiponectin and AMP-activated protein kinase in breast cancer survivors.

作者信息

Babaei Zeinab, Parsian Hadi, Korani Bahare, Mostafazadeh Amrollah, Moslemi Dariush

机构信息

Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

出版信息

J Res Med Sci. 2022 Jun 30;27:48. doi: 10.4103/jrms.JRMS_453_20. eCollection 2022.

DOI:10.4103/jrms.JRMS_453_20
PMID:35968203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9374150/
Abstract

BACKGROUND

Available data suggest that obesity is related to changes in the several adipocyte-derived proteins levels, which are involved in cancer recurrence. The purpose of this work was to investigate the correlation between obesity with metalloproteinase-9 (MMP-9), adiponectin and adiponectin and AMP-activated protein kinase (AMPK) levels by comparing serum levels of MMP-9, AMPK in normal weight and obese breast cancer survivors.

MATERIALS AND METHODS

In this cross-sectional study, 30 normal weight breast cancer survivors (body mass index [BMI] 18.5-25 kg/m) and 30 obese breast cancer survivors (BMI ≥30 kg/m) were investigated. Anthropometric parameters and serum levels of MMP-9, adiponectin, and AMPK were compared between the two groups.

RESULTS

No differences were detected in the serum levels of MMP-9, adiponectin, and AMPK in obese patients and normal weight patients ( > 0.05). There were no correlations between MMP-9, adiponectin, and AMPK levels with anthropometric measurements in two groups ( > 0.05).

CONCLUSION

We found that there was a lack of correlation between obesity measures and serum levels of MMP-9, adiponectin, and AMPK. In breast cancer survivors, it seems that circulating levels of adiponectin, AMPK, and MMP-9 do not change in obesity state.

摘要

背景

现有数据表明，肥胖与几种脂肪细胞衍生蛋白水平的变化有关，这些蛋白与癌症复发有关。本研究的目的是通过比较正常体重和肥胖乳腺癌幸存者的血清中基质金属蛋白酶-9（MMP-9）、脂联素以及脂联素与AMP活化蛋白激酶（AMPK）的水平，来研究肥胖与它们之间的相关性。

材料与方法

在这项横断面研究中，对30名正常体重的乳腺癌幸存者（体重指数[BMI]为18.5 - 25kg/m²）和30名肥胖的乳腺癌幸存者（BMI≥30kg/m²）进行了调查。比较了两组的人体测量参数以及血清中MMP-9、脂联素和AMPK的水平。

结果

肥胖患者和正常体重患者的血清中MMP-9、脂联素和AMPK水平未检测到差异（P>0.05）。两组中MMP-9、脂联素和AMPK水平与人体测量指标之间均无相关性（P>0.05）。

结论

我们发现肥胖指标与血清中MMP-9、脂联素和AMPK水平之间缺乏相关性。在乳腺癌幸存者中，肥胖状态下脂联素、AMPK和MMP-9的循环水平似乎没有变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c783/9374150/62235477b97e/JRMS-27-48-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c783/9374150/62235477b97e/JRMS-27-48-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c783/9374150/62235477b97e/JRMS-27-48-g001.jpg

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