Yan Wei, Feng Xiaomiao, Chen Xiaojun, Li Xinghua, Zhu Jun-Jie
Key Laboratory of Analytical Chemistry for Life Science (MOE), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
Bioelectrochemistry. 2008 Feb;72(1):21-7. doi: 10.1016/j.bioelechem.2007.07.003. Epub 2007 Jul 25.
Silver chloride@polyaniline (PANI) core-shell (AgCl@PANI) nanocomposites were synthesized in the presence of polyvinylpyrrolidone (PVP). The obtained AgCl@PANI nanocomposites could be easily dispersed in aqueous media, which overcame the processible issues of PANI. Moreover, the nanocomposites showed excellent electrochemical behavior at pH neutral environment, and had inhibitive effect on oxidation of ascorbic acid. Fourier transform infrared spectrophotometry (FTIR) confirmed the existence of PVP in the nanocomposites. The C=O group of PVP is easy to form hydrogen bonding with the hydroxyl group of ascorbic acid, which can prevent ascorbic acid from oxidization. A selective dopamine biosensor was constructed based on the particular characteristic of the AgCl@PANI nanocomposites by the simple drop-coating. The biosensor could detect dopamine at its very low concentration in the presence of 5000 time concentration of ascorbic acid at neutral environment.
在聚乙烯吡咯烷酮（PVP）存在的情况下合成了氯化银@聚苯胺（PANI）核壳（AgCl@PANI）纳米复合材料。所制备的AgCl@PANI纳米复合材料能够轻松分散于水性介质中，这克服了聚苯胺的加工问题。此外，该纳米复合材料在pH中性环境下展现出优异的电化学行为，并且对抗坏血酸的氧化具有抑制作用。傅里叶变换红外光谱法（FTIR）证实了纳米复合材料中存在PVP。PVP的C=O基团易于与抗坏血酸的羟基形成氢键，从而能够防止抗坏血酸被氧化。基于AgCl@PANI纳米复合材料的特殊性质，通过简单的滴涂法构建了一种选择性多巴胺生物传感器。该生物传感器能够在中性环境中，在存在浓度为其5000倍的抗坏血酸的情况下，检测到极低浓度的多巴胺。
