电化学检测多巴胺的新趋势。
New trends in the electrochemical sensing of dopamine.
机构信息
Faculty of Chemistry, University of Warsaw, 02-093 Warsaw, Poland.
出版信息
Anal Bioanal Chem. 2013 Apr;405(11):3753-71. doi: 10.1007/s00216-012-6578-2. Epub 2012 Dec 16.
Since the early 70s electrochemistry has been used as a powerful analytical technique for monitoring electroactive species in living organisms. In particular, after extremely rapid evolution of new micro and nanotechnology it has been established as an invaluable technique ranging from experiments in vivo to measurement of exocytosis during communication between cells under in vitro conditions. This review highlights recent advances in the development of electrochemical sensors for selective sensing of one of the most important neurotransmitters--dopamine. Dopamine is an electroactive catecholamine neurotransmitter, abundant in the mammalian central nervous system, affecting both cognitive and behavioral functions of living organisms. We have not attempted to cover a large time-span nor to be comprehensive in presenting the vast literature devoted to electrochemical dopamine sensing. Instead, we have focused on the last five years, describing recent progress as well as showing some problems and directions for future development.
自 70 年代初以来,电化学已被用作监测活体生物中电活性物质的强大分析技术。特别是,在微纳新技术迅速发展之后,它已经成为一种非常有价值的技术,涵盖了从体内实验到体外细胞间通讯过程中胞吐作用的测量。本文综述了电化学传感器在选择性检测最重要的神经递质之一——多巴胺方面的最新进展。多巴胺是一种电活性儿茶酚胺神经递质,在哺乳动物中枢神经系统中含量丰富,影响生物的认知和行为功能。我们没有试图涵盖很长的时间跨度,也没有全面介绍致力于电化学多巴胺传感的大量文献。相反,我们专注于过去五年,描述了最近的进展,并展示了一些问题和未来发展的方向。