Chu Susan Y, Kim Shin Y, Lau Joseph, Schmid Christopher H, Dietz Patricia M, Callaghan William M, Curtis Kathryn M
Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Am J Obstet Gynecol. 2007 Sep;197(3):223-8. doi: 10.1016/j.ajog.2007.03.027.
We conducted this metaanalysis to summarize the available epidemiologic evidence on the relationship between maternal overweight and obesity and the risk of stillbirth. We identified studies from 3 sources: (1) a PubMed search of relevant articles that were published between January 1980 and September 2005, (2) reference lists of publications that were selected from the PubMed search, and (3) reference lists of review articles on obesity and maternal outcomes that were published between 2000 and 2005. We used a Bayesian random effects model to perform the metaanalysis and metaregression. Nine studies were included in the metaanalysis. The unadjusted odds ratios of a stillbirth were 1.47 (95% CI, 1.08-1.94) and 2.07 (95% CI, 1.59-2.74) among overweight and obese pregnant women, respectively, compared with normal-weight pregnant women. The metaregression analysis found no evidence that these estimates were affected by selected study characteristics. Maternal obesity is associated with an increased risk of stillbirth, although the mechanisms to explain this association are not clear.
我们开展了这项荟萃分析，以总结关于孕产妇超重和肥胖与死产风险之间关系的现有流行病学证据。我们从3个来源确定了研究：（1）对1980年1月至2005年9月发表的相关文章进行PubMed检索；（2）从PubMed检索中选择的出版物的参考文献列表；（3）2000年至2005年发表的关于肥胖与孕产妇结局的综述文章的参考文献列表。我们使用贝叶斯随机效应模型进行荟萃分析和元回归分析。9项研究纳入了荟萃分析。与体重正常的孕妇相比，超重和肥胖孕妇的未调整死产比值比分别为1.47（95%CI，1.08 - 1.94）和2.07（95%CI，1.59 - 2.74）。元回归分析未发现证据表明这些估计值受所选研究特征的影响。孕产妇肥胖与死产风险增加相关，尽管解释这种关联的机制尚不清楚。
