Matsumoto Takayuki, Kudo Tetsuji, Jo Yukihiko, Esaki Motohiro, Yao Takashi, Iida Mitsuo
Departments of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Gastrointest Endosc. 2007 Nov;66(5):957-65. doi: 10.1016/j.gie.2007.04.014. Epub 2007 Sep 12.
Narrow-band imaging (NBI) is a novel illumination technology for endoscopy that enhances vasculature of the GI tract.
The aim was to elucidate whether NBI colonoscopy can identify dysplasia in patients with ulcerative colitis (UC).
Cross-sectional study of eligible patients.
Single center.
46 patients with UC.
Apparently flat mucosa at each segment and visible protruding lesions were observed by magnifying NBI colonoscopy. The surface structure was classified into honeycomb-like, villous, or tortuous pattern. The grade of dysplasia was determined in the specimens obtained from protrusions and from flat mucosa.
The positive predictive value of conventional and NBI colonoscopy for the diagnosis of dysplasia.
A total of 296 sites (20 protruding lesions and 276 flat areas) were examined by NBI colonoscopy. The surface pattern was determined to be honeycomb like in 161 sites, villous in 85 sites, and tortuous in 50 sites. Five dysplastic lesions were detected in 3 patients. A patient had 3 dysplastic lesions and the other 2 had a dysplastic lesion each. The positive rate of dysplasia was higher in protrusions (2/20 sites, 10%) than in flat mucosa (3/276 sites, 1.1%, P = .038; however, correction for the multiple testing of data removes this significance). When the surface pattern was taken into account, the rate of positive dysplasia was higher in the tortuous pattern (4/50 sites, 8%) than in the honeycomb-like or villous patterns (1/246 sites, 0.4%, P = .003).
Uncontrolled study.
The tortuous pattern determined by NBI colonoscopy may be a clue for the identification of dysplasia during surveillance for UC.
窄带成像（NBI）是一种用于内镜检查的新型照明技术，可增强胃肠道的血管成像。
旨在阐明NBI结肠镜检查能否识别溃疡性结肠炎（UC）患者的发育异常。
对符合条件的患者进行横断面研究。
单中心。
46例UC患者。
通过放大NBI结肠镜检查观察每个节段的表面平坦黏膜和可见的突出病变。表面结构分为蜂窝状、绒毛状或迂曲状。从突出病变和平坦黏膜获取的标本中确定发育异常的等级。
传统结肠镜检查和NBI结肠镜检查对发育异常诊断的阳性预测值。
NBI结肠镜检查共检查了296个部位（20个突出病变和276个平坦区域）。表面模式确定为蜂窝状161个部位，绒毛状85个部位，迂曲状50个部位。在3例患者中检测到5个发育异常病变。1例患者有3个发育异常病变，另外2例各有1个发育异常病变。突出病变中发育异常的阳性率（2/20个部位，10%）高于平坦黏膜（3/276个部位，1.1%，P = 0.038；然而，对数据进行多重检验校正后消除了这种显著性）。考虑表面模式时，迂曲状模式中发育异常阳性率（4/50个部位，8%）高于蜂窝状或绒毛状模式（1/246个部位，0.4%，P = 0.003）。
非对照研究。
NBI结肠镜检查确定的迂曲状模式可能是UC监测期间识别发育异常的线索。
