荧光成像结肠镜检查在溃疡性结肠炎中对异型增生性病变的检测：一项初步研究。
Autofluorescence imaging colonoscopy for the detection of dysplastic lesions in ulcerative colitis: a pilot study.
机构信息
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Colorectal Dis. 2010 Oct;12(10 Online):e291-7. doi: 10.1111/j.1463-1318.2009.02181.x.
AIM
Autofluorescence imaging (AFI) is a novel technology for endoscopy, which enhances neoplastic lesions of the gastrointestinal tract. The aim of this investigation was to examine whether AFI colonoscopy can identify dysplasia in ulcerative colitis.
METHOD
We examined 48 patients with ulcerative colitis by AFI colonoscopy. Apparently flat, coarse granular mucosa and visible protruding lesions under conventional colonoscopy were observed by AFI. Those target areas were classified into low AF and high AF according to the colour under AFI colonoscopy. The grade of dysplasia was determined in the specimens obtained from the target areas.
RESULTS
About 126 sites (35 protruding lesions and 91 flat areas) were examined by AFI colonoscopy. AF was determined to be high in 42 areas and to be low in 84 areas. The positive rate of dysplasia was higher in protrusions (31%) than in flat mucosa (3.3%, P < 0.0001). The rate of positive dysplasia was not statistically different between lesions determined to be low AF (14%) and those to be high AF (5%, P = 0.09). The positive rate of dysplasia in protruding lesions was significantly higher in low AF than in high AF (45.0%vs 13.3%, P = 0.043), while the value in flat lesions was not different between low AF and high AF (8.2%vs 0%, P = 0.3).
CONCLUSIONS
Autofluorescence imaging colonoscopy seems to have a role for the detection of dysplaia in ulcerative colitis.
目的
自发荧光成像（AFI）是一种用于内窥镜检查的新型技术，可增强胃肠道的肿瘤病变。本研究旨在检查 AFI 结肠镜检查是否可以识别溃疡性结肠炎中的异型增生。
方法
我们通过 AFI 结肠镜检查检查了 48 例溃疡性结肠炎患者。在常规结肠镜检查下观察到明显平坦、粗糙颗粒状的黏膜和可见的突出病变，通过 AFI 进行观察。根据 AFI 结肠镜下的颜色，将这些目标区域分为低 AF 和高 AF。从目标区域获得的标本中确定异型增生的程度。
结果
通过 AFI 结肠镜检查检查了约 126 个部位（35 个突出病变和 91 个平坦区域）。AF 在 42 个区域中被确定为高，在 84 个区域中被确定为低。隆起处异型增生的阳性率（31%）高于平坦黏膜（3.3%，P<0.0001）。低 AF 病变（14%）和高 AF 病变（5%）之间的阳性异型增生率无统计学差异（P=0.09）。低 AF 隆起病变中异型增生的阳性率明显高于高 AF（45.0%vs 13.3%，P=0.043），而平坦病变中低 AF 和高 AF 之间的阳性率无差异（8.2%vs 0%，P=0.3）。
结论
自发荧光成像结肠镜检查似乎在溃疡性结肠炎异型增生的检测中具有一定作用。
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