Terent'eva T G, Torbochkina L I, Bobikov E V, Sokolov A B, Aniskina R I
Antibiotiki. 1975 Nov;20(11):1032-5.
Penetration of variamycin, a new antitumor antibiotic into the normal and tumor tissues of the brain of rats with multiform glioblastoma was investigated. The content of the C14-labeled antibiotic was determined radiometrically. The radioactive label penetrated into the normal and tumor tissues of the brain during the first hours after the drug administration. The level of the radioactivity in the tumor tissue was higher than that in the normal brain tissue during the whole period of the study. The greatest deviation in the contents of the radioactive label in the tumor and normal tissues was observed 2 and 3 hours after administration of the labeled antibiotic, i. e. 4.3 and 3.6 times respectively.
研究了新型抗肿瘤抗生素变霉素对多形性胶质母细胞瘤大鼠脑正常组织和肿瘤组织的渗透情况。采用放射性测量法测定了C14标记抗生素的含量。给药后的最初几个小时内，放射性标记物渗透到脑的正常组织和肿瘤组织中。在整个研究期间，肿瘤组织中的放射性水平高于正常脑组织。在给予标记抗生素后2小时和3小时观察到肿瘤组织和正常组织中放射性标记物含量的最大偏差，分别为4.3倍和3.6倍。
