Hay Anne-Emmanuelle, Merza Joumaa, Landreau Anne, Litaudon Marc, Pagniez Fabrice, Le Pape Patrice, Richomme Pascal
SONAS, UFR des Sciences Pharmaceutiques et d'Ingénierie de la Santé, 16 Bd Daviers, 49100 Angers, France.
Fitoterapia. 2008 Jan;79(1):42-6. doi: 10.1016/j.fitote.2007.07.005. Epub 2007 Aug 9.
Seven xanthones, the new vieillardiixanthones B and C (1) and (7), pancixanthones A (2), B (3), 1,6-dihydroxyxanthone (6), pyranojacareubin and 5,6-O-dimethyl-2-deprenylrheediaxanthone together with two benzophenones, clusiachromene (4) and 3-geranyl-2,4,6-trihydroxybenzophenone (5) were isolated from the stem bark of the neocaledonian Garcinia vieillardii. 2, 5 and 6 showed a significant antileishmanial activity against the promastigote forms of Leishmania mexicana and L. infantum and against the amastigote forms of L. infantum.
从新喀里多尼亚藤黄（Garcinia vieillardii）的茎皮中分离出七种呫吨酮，即新的维氏藤黄呫吨酮B和C（1）和（7）、泛呫吨酮A（2）、B（3）、1,6 - 二羟基呫吨酮（6）、吡喃型巴西苏木素和5,6 - O - 二甲基 - 2 - 去甲异戊二烯基红厚壳呫吨酮，以及两种二苯甲酮，即藤黄色烯（4）和3 - 香叶基 - 2,4,6 - 三羟基二苯甲酮（5）。化合物2、5和6对墨西哥利什曼原虫和婴儿利什曼原虫的前鞭毛体形式以及婴儿利什曼原虫的无鞭毛体形式显示出显著的抗利什曼原虫活性。
