Department of Natural Product Development and Formulations, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Fitoterapia. 2010 Jul;81(5):420-3. doi: 10.1016/j.fitote.2009.12.002. Epub 2009 Dec 16.
Phytochemical investigation on the root bark of Garcinia edulis (Clusiaceae) gave a new isoprenylated xanthone, 1,4,6-trihydroxy-3-methoxy-2-(3-methyl-2-butenyl)-5-(1,1-dimethyl-prop-2-enyl)xanthone (1), a known xanthone, forbexanthone (2) together with three known pentacyclic triterpenoids, friedelin, lupeol and lupeol acetate. The structure of the new compound was fully characterised by NMR spectroscopic analysis. Compound 1 showed significant anti-HIV-1 protease activity with IC(50) value of 11.3 microg/mL. Furthermore, compound 1 showed potent cytotoxic activity with LC(50) value of 2.36 microg/mL against brine shrimp larva in vitro.
植物化学研究表明，藤黄科藤黄属植物厚叶胡桐（Garcinia edulis）的根皮中含有一种新的异戊烯基黄烷酮，即 1,4,6-三羟基-3-甲氧基-2-(3-甲基-2-丁烯基)-5-(1,1-二甲基-2-丙烯基)黄烷酮（1），同时还含有另一种已知的黄烷酮化合物福贝紫檀酮（2）以及三种已知的五环三萜类化合物，分别为羽扇豆醇、羽扇豆醇乙酸酯和无羁萜。新化合物的结构通过核磁共振波谱分析得到了充分的表征。化合物 1 对 HIV-1 蛋白酶表现出显著的抑制活性，其半数抑制浓度（IC50）值为 11.3μg/mL。此外，化合物 1 对卤虫幼虫的体外细胞毒性活性较强，半数致死浓度（LC50）值为 2.36μg/mL。
