藤黄属植物中具有生物活性的异戊烯基黄烷酮和其他成分。

A bioactive isoprenylated xanthone and other constituents of Garcinia edulis.

机构信息

Department of Natural Product Development and Formulations, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

出版信息

Fitoterapia. 2010 Jul;81(5):420-3. doi: 10.1016/j.fitote.2009.12.002. Epub 2009 Dec 16.

DOI:10.1016/j.fitote.2009.12.002

PMID:20006684

Abstract

Phytochemical investigation on the root bark of Garcinia edulis (Clusiaceae) gave a new isoprenylated xanthone, 1,4,6-trihydroxy-3-methoxy-2-(3-methyl-2-butenyl)-5-(1,1-dimethyl-prop-2-enyl)xanthone (1), a known xanthone, forbexanthone (2) together with three known pentacyclic triterpenoids, friedelin, lupeol and lupeol acetate. The structure of the new compound was fully characterised by NMR spectroscopic analysis. Compound 1 showed significant anti-HIV-1 protease activity with IC(50) value of 11.3 microg/mL. Furthermore, compound 1 showed potent cytotoxic activity with LC(50) value of 2.36 microg/mL against brine shrimp larva in vitro.

摘要

植物化学研究表明，藤黄科藤黄属植物厚叶胡桐（Garcinia edulis）的根皮中含有一种新的异戊烯基黄烷酮，即 1,4,6-三羟基-3-甲氧基-2-(3-甲基-2-丁烯基)-5-(1,1-二甲基-2-丙烯基)黄烷酮（1），同时还含有另一种已知的黄烷酮化合物福贝紫檀酮（2）以及三种已知的五环三萜类化合物，分别为羽扇豆醇、羽扇豆醇乙酸酯和无羁萜。新化合物的结构通过核磁共振波谱分析得到了充分的表征。化合物 1 对 HIV-1 蛋白酶表现出显著的抑制活性，其半数抑制浓度（IC50）值为 11.3μg/mL。此外，化合物 1 对卤虫幼虫的体外细胞毒性活性较强，半数致死浓度（LC50）值为 2.36μg/mL。