Tian L
Department of Pathology, Hebei Provincial Hospital, Shijiazhuang.
Zhonghua Bing Li Xue Za Zhi. 1991 Sep;20(3):211-3.
Experimental varicoceles were created in adult male Wistar rats by partially occluding the left renal vein. The affect of the varicocele on ipsilateral testis was studied at intervals over 15 weeks via ultrathin sections and freeze-etching replica technique examined under electron microscope. Observations showed that varicocele resulted in injuries of Sertoli-Sertoli cell and Sertoli cell-spermatid junctional complexes. Abnormal changes of Sertoli cell-spermatid junctional complexes might lead to spermiogenic arrest and spermatids slough, while those of Sertoli-Sertoli cell junctional complexes to dysfunction of barrier and abnormal alteration of microenvironment of seminiferous tubule. Probably, this is one of the reasons that the fertility was not improved in some patients even after high level ligation of the internal spermatic vein.
通过部分阻断成年雄性Wistar大鼠的左肾静脉来制造实验性精索静脉曲张。在15周的时间里，通过超薄切片和冷冻蚀刻复型技术在电子显微镜下检查，间隔研究精索静脉曲张对同侧睾丸的影响。观察结果表明，精索静脉曲张导致支持细胞-支持细胞连接复合体和支持细胞-精子细胞连接复合体受损。支持细胞-精子细胞连接复合体的异常变化可能导致精子发生停滞和精子细胞脱落，而支持细胞-支持细胞连接复合体的异常变化则导致屏障功能障碍和生精小管微环境的异常改变。这可能是一些患者即使在精索内静脉高位结扎后生育能力仍未改善的原因之一。
