Cameron D F, Snydle F E, Ross M H, Drylie D M
Fertil Steril. 1980 May;33(5):526-33. doi: 10.1016/s0015-0282(16)44719-9.
Testicular biopsies from 21 otherwise healthy men with diagnosed varicocele were processed for light and electron microscopy. Whereas germ cell morphology and tissue architecture of the basal testicular compartment appeared normal, cellular mophology and intercellular associations of the adluminal testicular compartment were variably altered. In affected tubules, spermatid nuclear and acrosomal morphology was abnormal and sloughing was evident. Spermatids were maloriented relative to Sertoli cells, and Sertoli-germ cell junctional complexes appeared to be structurally abnormal. Contradistinctly, Sertoli-Sertoli cell junctional complexes appeared unaffected. Results from this study indicate that testicular disruption in varicocele is a phenomenon of the adluminal compartment, that the Sertoli cell is, in fact, more sensitive to perturbation of the testicular environment than are germ cells, and that the Sertoli cell is the primary intratubular site of alteration leading secondarily to spermatogenic disruption.
对21名确诊患有精索静脉曲张但其他方面健康的男性进行睾丸活检，用于光镜和电镜检查。虽然睾丸基部区域的生殖细胞形态和组织结构看起来正常，但近腔区域的细胞形态和细胞间联系却有不同程度的改变。在受影响的曲细精管中，精子细胞核和顶体形态异常，且明显有脱落现象。相对于支持细胞，精子细胞的取向异常，支持细胞与生殖细胞的连接复合体在结构上似乎也不正常。截然不同的是，支持细胞与支持细胞的连接复合体似乎未受影响。本研究结果表明，精索静脉曲张时睾丸破坏是近腔区域的一种现象，事实上，支持细胞比生殖细胞对睾丸环境的扰动更敏感，并且支持细胞是导致生精破坏的主要管内改变部位。
