健康与癌症中天然抗Thomson-Friedenreich 抗原抗体的分析：多样性与临床潜力。
Profiling of Naturally Occurring Antibodies to the Thomsen-Friedenreich Antigen in Health and Cancer: The Diversity and Clinical Potential.
机构信息
Department of Virology and Immunology, National Institute for Health Development, Hiiu 42, Tallinn 11619, Estonia.
出版信息
Biomed Res Int. 2020 Mar 23;2020:9747040. doi: 10.1155/2020/9747040. eCollection 2020.
Abstract
The Thomsen-Friedenreich (TF) antigen is expressed in a majority of human tumors due to aberrant glycosylation in cancer cells. There is strong evidence that humoral immune response to TF represents an effective mechanism for the elimination of cancer cells that express TF-positive glycoconjugates. The presence of naturally occurring antibodies to tumor-associated TF and cancer-specific changes in their levels, isotype distribution and interrelation, avidity, and glycosylation profile make these Abs a convenient and ubiquitous marker for cancer diagnostics and prognostics. In this review, we attempt to summarize the latest data on the potential of TF-specific Abs for cancer diagnostics and prognostics.
摘要
Thomson-Friedenreich（TF）抗原在大多数人类肿瘤中表达，这是由于癌细胞中的异常糖基化。有强有力的证据表明，针对 TF 的体液免疫反应是消除表达 TF 阳性糖缀合物的癌细胞的有效机制。存在针对肿瘤相关 TF 的天然存在的抗体以及其水平、同种型分布和相互关系、亲合力和糖基化谱的变化，使得这些 Abs 成为癌症诊断和预后的方便和普遍的标志物。在这篇综述中，我们试图总结 TF 特异性 Abs 在癌症诊断和预后中的最新数据。
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