Irle Eva, Lange Claudia, Weniger Godehard, Sachsse Ulrich
Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, D-37075 Göttingen, Germany.
Psychiatry Res. 2007 Nov 15;156(2):139-49. doi: 10.1016/j.pscychresns.2007.01.007. Epub 2007 Sep 10.
Recent evidence suggests that borderline personality disorder (BPD) is related to reduced size of the parietal lobe. Dissociative symptoms occur in the majority of individuals with BPD. Structural magnetic resonance imaging (3D-MRI) was used to assess volumes of the superior (precuneus, postcentral gyrus) and inferior parietal cortices in 30 young women with BPD who had been exposed to severe childhood sexual and physical abuse and 25 healthy control subjects. Compared with control subjects, BPD subjects had significantly smaller right-sided precuneus (-9%) volumes. The left postcentral gyrus of BPD subjects with the comorbid diagnosis of dissociative amnesia (DA) or dissociative identity disorder (DID) was significantly increased compared with controls (+13%) and compared with BPD subjects without these disorders (+11%). In BPD subjects, stronger depersonalization was significantly related to larger right precuneus size. Possibly, larger precuneus size in BPD is related to symptoms of depersonalization. Increased postcentral gyrus size in BPD may be related to the development of DA or DID in the presence of severe childhood abuse.
近期证据表明，边缘型人格障碍（BPD）与顶叶体积减小有关。解离症状在大多数BPD患者中出现。采用结构磁共振成像（3D-MRI）评估了30名曾遭受严重童年期性虐待和身体虐待的BPD年轻女性以及25名健康对照者的顶上叶（楔前叶、中央后回）和顶下叶皮质体积。与对照者相比，BPD患者右侧楔前叶体积显著更小（-9%）。与对照者相比（+13%）以及与无这些障碍的BPD患者相比（+11%），共病解离性遗忘（DA）或解离性身份障碍（DID）的BPD患者左侧中央后回显著增大。在BPD患者中，更强的人格解体与右侧楔前叶更大的体积显著相关。BPD患者楔前叶体积增大可能与人格解体症状有关。BPD患者中央后回增大可能与在童年期严重虐待情况下DA或DID的发生有关。
