Tung Yu-Tang, Chua Meng-Thong, Wang Sheng-Yang, Chang Shang-Tzen
School of Forestry and Resource Conservation, National Taiwan University, Taipei 106, Taiwan.
Bioresour Technol. 2008 Jun;99(9):3908-13. doi: 10.1016/j.biortech.2007.07.050. Epub 2007 Sep 10.
In this study, chemical compositions of hydrodistilled essential oil and anti-inflammatory activities from the twigs of Cinnamomum osmophloeum Kaneh. were investigated for the first time. The chemical constituents of the twig essential oil were further analyzed by GC-MS and they were found to be L-bornyl acetate (15.89%), caryophyllene oxide (12.98%), gamma-eudesmol (8.03%), beta-caryophyllene (6.60%), T-cadinol (5.49%), delta-cadinene (4.79%), trans-beta-elemenone (4.25%), cadalene (4.19%), and trans-cinnamaldehyde (4.07%). The effects of essential oil on nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were also examined. Results of nitric oxide tests indicated that twig essential oil and its major constituents such as trans-cinnamaldehyde, caryophyllene oxide, L-borneol, L-bornyl acetate, eugenol, beta-caryophyllene, E-nerolidol, and cinnamyl acetate have excellent activities. These findings demonstrated that essential oil of C. osmophloeum twigs have excellent anti-inflammatory activities and thus have great potential to be used as a source for natural health products.
本研究首次对土肉桂嫩枝的水蒸馏精油化学成分及其抗炎活性进行了研究。采用气相色谱-质谱联用仪（GC-MS）对嫩枝精油的化学成分进行了进一步分析，结果发现其主要成分为L-乙酸龙脑酯（15.89%）、氧化石竹烯（12.98%）、γ-桉叶醇（8.03%）、β-石竹烯（6.60%）、T-杜松醇（5.49%）、δ-杜松烯（4.79%）、反式-β-榄香烯酮（4.25%）、杜松烯（4.19%）和反式肉桂醛（4.07%）。此外，还考察了该精油对脂多糖（LPS）激活的RAW 264.7巨噬细胞中一氧化氮（NO）和前列腺素E2（PGE2）生成的影响。一氧化氮检测结果表明，嫩枝精油及其主要成分如反式肉桂醛、氧化石竹烯、L-冰片、L-乙酸龙脑酯、丁香酚、β-石竹烯、E-橙花叔醇和乙酸肉桂酯具有优异的活性。这些研究结果表明，土肉桂嫩枝精油具有优异的抗炎活性，因此具有作为天然保健品来源的巨大潜力。
