通过趋化因子嗜酸性粒细胞趋化蛋白/CCL11区分麻风病患者与未感染个体。
Differentiation of patients with leprosy from non-infected individuals by the chemokine eotaxin/CCL11.
作者信息
Mendonça Vanessa A, Malaquias Luiz C, Brito-Melo Gustavo E, Castelo-Branco Alexandre, Antunes Carlos M, Ribeiro Antonio L, Teixeira Mauro M, Teixeira Antonio L
机构信息
Laboratório de Imunofarmacologia, Instituto de Ciências Biológicas, e Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
出版信息
Am J Trop Med Hyg. 2007 Sep;77(3):547-50.
Diagnosis of leprosy is usually made clinically and there are no tests available for the routine laboratory diagnosis of the disease. The aim of this study was to investigate the potential role of chemokines as biologic markers of disease activity. We used an enzyme-linked immunosorbent assay to measure chemokines in plasma of patients with leprosy (LE) and non-infected (NI) individuals. There were significantly greater concentrations of the chemokines CCL3 and CCL11 in plasma of LE patients than in NI individuals. When the use of CCL11 to differentiate LE patients versus NI individuals was evaluated, the area under the receiver-operator-characteristic curve was 0.95 +/- 0.03 (P < 0.0001). In a group of selected individuals, CCL11 was useful in diagnosis of leprosy, thereby suggesting that measurement of this chemokine may be useful as an aid in diagnosing leprosis.
麻风病通常通过临床诊断，目前尚无用于该疾病常规实验室诊断的检测方法。本研究的目的是调查趋化因子作为疾病活动生物标志物的潜在作用。我们使用酶联免疫吸附测定法来测量麻风病（LE）患者和未感染（NI）个体血浆中的趋化因子。LE患者血浆中趋化因子CCL3和CCL11的浓度显著高于NI个体。当评估使用CCL11区分LE患者和NI个体时，受试者工作特征曲线下面积为0.95±0.03（P<0.0001）。在一组选定个体中，CCL11有助于麻风病的诊断，因此表明测量这种趋化因子可能有助于麻风病的诊断。
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