Maggi Julie D, Halman Mark H
St. Michael's Hospital, Mental Health Service, and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
J Neuropsychiatry Clin Neurosci. 2007 Summer;19(3):326-30. doi: 10.1176/jnp.2007.19.3.326.
In vitro data suggest valproate activates HIV replication. This study prospectively assesses whether divalproex sodium causes an increase in HIV replication in patients. Eight participants had their HIV viral load measured over approximately 1 month. The largest increases in viral load occurred in patients without antiretroviral medication. No patients had an increase in Log10 HIV viral load > or = 0.5. Further study is needed to understand implications.
体外数据表明丙戊酸盐可激活HIV复制。本研究前瞻性评估丙戊酸钠是否会导致患者体内HIV复制增加。8名参与者在约1个月的时间内测量了HIV病毒载量。病毒载量增加最多的情况发生在未接受抗逆转录病毒药物治疗的患者中。没有患者的Log10 HIV病毒载量增加≥0.5。需要进一步研究以了解其中的影响。
