Sasaki Takehiko, Sasaki Junko, Sakai Takahiro, Takasuga Shunsuke, Suzuki Akira
Department of Pathology and Immunology, Division of Microbiology, Akita University School of Medicine, Akita, Japan.
Biol Pharm Bull. 2007 Sep;30(9):1599-604. doi: 10.1248/bpb.30.1599.
Phosphoinositides are a family of phosphorylated derivatives of the membrane lipid phosphatidylinositol. These lipids are highly concentrated in distinct pools located in a cell's plasma membrane, endosomes or nucleus, where they function as ligands for phosphoinositide-binding proteins. Protein domains that bind phosphoinositides include the pleckstrin homology (PH) domain, the phox homology (PX) domain and the Fab1p-YOPB-Vps27p-EEA1 (FYVE) domain. These domains are found in many proteins involved in intracellular signaling, membrane trafficking and cytoskeletal rearrangement. Recent studies have identified potential links between alterations to various signaling pathways involving phosphoinositides and the etiology of many human diseases.
磷酸肌醇是膜脂磷脂酰肌醇的磷酸化衍生物家族。这些脂质高度集中在位于细胞的质膜、内体或细胞核中的不同区域，在那里它们作为磷酸肌醇结合蛋白的配体发挥作用。结合磷酸肌醇的蛋白质结构域包括普列克底物蛋白同源（PH）结构域、吞噬细胞氧化酶同源（PX）结构域和Fab1p-YOPB-Vps27p-EEA1（FYVE）结构域。这些结构域存在于许多参与细胞内信号传导、膜运输和细胞骨架重排的蛋白质中。最近的研究已经确定了涉及磷酸肌醇的各种信号通路改变与许多人类疾病病因之间的潜在联系。
