Huang Hui-Chi, Tsai Wei-Jern, Liaw Chia-Ching, Wu Shih-Hsiung, Wu Yang-Chang, Kuo Yao-Haur
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chem Pharm Bull (Tokyo). 2007 Sep;55(9):1412-5. doi: 10.1248/cpb.55.1412.
Bioassay-directed fractionation of an ethanolic extract of the galls of Sapindus mukorossi has resulted in the isolation of two new tirucallane-type triterpenoid saponins, sapinmusaponins Q (1) and R (2), along with three known oleanane-type triterpenoid saponins (3-5). Their structures were elucidated on the basis of spectroscopic analysis and chemical hydrolysis. Biological evaluation showed that both sapinmusaponins Q and R demonstrated more potent anti-platelet aggregation activity than aspirin.
对无患子瘿乙醇提取物进行生物活性导向的分离，得到了两种新的羽扇豆烷型三萜皂苷，无患子皂苷Q（1）和R（2），以及三种已知的齐墩果烷型三萜皂苷（3 - 5）。通过光谱分析和化学水解阐明了它们的结构。生物活性评价表明，无患子皂苷Q和R均表现出比阿司匹林更强的抗血小板聚集活性。
