轮叶党参的三萜皂苷及其抗炎活性

Triterpenoid saponins and anti-inflammatory activity of Codonopsis lanceolata.

作者信息

Li Jian-Ping, Liang Zhi-Min, Yuan Zhong

机构信息

School of Pharmacy, Changchun College of Traditional Chinese Medicine, Changchun, People's Republic of China.

出版信息

Pharmazie. 2007 Jun;62(6):463-6.

PMID:17663196

Abstract

The ethanolic root extract of Codonopsis lanceolata were evaluated for anti-inflammatory activity using the carrageenan induced rat hind paw edema model and displayed a significant activity of 51.82% inhibition at 200 mg/kg at 3 h (p < 0.05). Further isolation of the extract yielded two new triterpenoid saponins, named codonolaside I (1) and codonolaside II (2). The spectroscopic and chemical data revealed their structures to be 3-O-[beta-D-xylopyranosyl (1->3)-(6'-O-methyl)-beta-D-glucuronopyranosyl]-30, 16a-dihydroxyolean-12-ene-28-oic acid 28-O-[P-D-xylopyranosyl (1-->4)-alpha-L-rhamnpyranosyl (1-->2)-alpha-L-arabinopyranosyl] ester (1), and 3beta, 16alpha-dihydroxyolean-12-ene-28-oic acid 28-O-[beta-D-xylopyranosyl (1-->3)-beta-D-xylopyranosyl (1-->4)-alpha-L-rhamnpyranosyl (1-->2)-alpha-L-arabinopyranosyl] ester (2).

摘要

使用角叉菜胶诱导的大鼠后爪水肿模型，对轮叶党参乙醇根提取物的抗炎活性进行了评估，在200mg/kg剂量下3小时显示出51.82%的显著抑制活性（p<0.05）。对该提取物进一步分离得到两种新的三萜皂苷，命名为轮叶党参苷I（1）和轮叶党参苷II（2）。光谱和化学数据表明它们的结构分别为3-O-[β-D-吡喃木糖基（1→3）-（6'-O-甲基）-β-D-葡萄糖醛酸吡喃糖基]-30,16α-二羟基齐墩果-12-烯-28-酸28-O-[β-D-吡喃木糖基（1→4）-α-L-鼠李糖吡喃糖基（1→2）-α-L-阿拉伯糖吡喃糖基]酯（1），以及3β,16α-二羟基齐墩果-12-烯-28-酸28-O-[β-D-吡喃木糖基（1→3）-β-D-吡喃木糖基（1→4）-α-L-鼠李糖吡喃糖基（1→2）-α-L-阿拉伯糖吡喃糖基]酯（2）。