Marino Silvia, Sessa Edoardo, Di Lorenzo Giuseppe, Lanzafame Pietro, Scullica Gabriella, Bramanti Alessia, La Rosa Francesco, Iannizzotto Giancarlo, Bramanti Placido, Di Bella Paolo
IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.
Eur Neurol. 2007;58(4):193-7. doi: 10.1159/000107939. Epub 2007 Sep 7.
The purpose of this study is to assess the efficacy and the tolerability of a new vision-based non-intrusive eye tracker in a population composed of normal controls and in patients affected by nonadvanced Parkinson's disease (PD). PD patients characteristically have difficulty in sustaining repetitive motor actions. Previous studies showed a progressive bradykinesia and hypokinesia of pursuit ocular movements (POM) in advanced PD. We found that the values of POM were lower in PD patients than in normal controls (p < 0.001). In PD patients, the values correlated closely with Hoehn and Yahr stage and Unified Parkinson Disease Rating Scale motor subscore (p < 0.001, for both). Our data suggest that deficit in POM occurs also in nonadvanced PD patients and it is closely correlated with clinical scores. Thus, this vision-based system can be considered a new method to provide, noninvasively, measures of POM dysfunctions and can be used as reliable indices of disease severity in PD patients.
本研究的目的是评估一种新型基于视觉的非侵入式眼动追踪器在正常对照人群以及非晚期帕金森病（PD）患者中的疗效和耐受性。PD患者的典型特征是在维持重复性运动动作方面存在困难。先前的研究表明，晚期PD患者的追踪性眼球运动（POM）存在进行性运动迟缓及运动功能减退。我们发现，PD患者的POM值低于正常对照（p < 0.001）。在PD患者中，这些值与Hoehn和Yahr分期以及统一帕金森病评定量表运动分项评分密切相关（两者均为p < 0.001）。我们的数据表明，非晚期PD患者也存在POM缺陷，且与临床评分密切相关。因此，这种基于视觉的系统可被视为一种非侵入性地提供POM功能障碍测量的新方法，并可作为PD患者疾病严重程度的可靠指标。
