IRCCS Centro Neurolesi, Bonino-Pulejo, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy.
Neurol Sci. 2011 Feb;32(1):67-71. doi: 10.1007/s10072-010-0395-1. Epub 2010 Aug 21.
Multiple sclerosis (MS) patients frequently develop some form of ocular motor dysfunction during the disease. In previous studies, ocular motor abnormalities were found to correlate with clinical disability and with impaired cognitive performance. The objective of this study was to assess the pursuit ocular movement (POM) frequency in relapsing-remitting (RR) and secondary progressive (SP) MS patients by using a vision-based non-intrusive eye tracker. POM frequency was significantly lower (p < 0.001) in MS patients compared to normal controls. No differences between RR and SP-MS patients and no correlation between POM and expanded disability status scale (EDSS) score were found. This exploratory study suggests that our vision-based system is a new simple non-intrusive method showing impairment of POM values in MS patients, even in the absence of association with clinical disability (EDSS). Future works on larger cohorts of MS patients might validate this eye tracking in MS clinical practice.
多发性硬化症 (MS) 患者在疾病过程中经常会出现某种形式的眼球运动功能障碍。在以前的研究中，眼球运动异常与临床残疾和认知功能受损相关。本研究的目的是通过使用基于视觉的非侵入性眼动追踪器来评估复发缓解型 (RR) 和继发进展型 (SP) MS 患者的追踪眼球运动 (POM) 频率。与正常对照组相比，MS 患者的 POM 频率明显较低 (p < 0.001)。RR 和 SP-MS 患者之间没有差异，也没有发现 POM 与扩展残疾状态量表 (EDSS) 评分之间存在相关性。这项探索性研究表明，我们基于视觉的系统是一种新的简单非侵入性方法，即使在与临床残疾 (EDSS) 无关的情况下，也能显示 MS 患者 POM 值的损害。对更大的 MS 患者队列进行的未来研究可能会验证这种眼动追踪在 MS 临床实践中的应用。
