Xu X X, Zhao Y H, Liu J G
Department of Orthopaedics, 1st Teaching Hospital, Norman.
Chin Med J (Engl). 1991 Dec;104(12):1018-21.
To study the causes of osteopenia after plate fixation in the treatment of fractures and bone diseases, intact tibiae of 26 dogs were fixed by 3 different plates at various rigidities. The dogs were killed at 24 hours 3, 6, 12, 20 weeks. Disulphine blue was injected intravenously before killing. The results showed that in addition to stress shielding the disturbance of blood supply was the main cause of osteopenia in the early stage. Reaction to the implant might be another cause in the middle stage. The disuse of the affected limb was the most important factor in the late stage. Osteopenia can be treated by active exercises and normal weight-bearing before plate removal.
为研究骨折及骨疾病钢板固定术后骨质减少的原因，对26只犬的完整胫骨采用3种不同刚度的钢板进行固定。分别在术后24小时、3周、6周、12周和20周处死实验犬。处死前经静脉注射亚甲蓝。结果显示，除应力遮挡外，早期骨质减少的主要原因是血供障碍。中期对植入物的反应可能是另一个原因。后期患肢废用是最重要的因素。在取出钢板前，通过主动锻炼和正常负重可治疗骨质减少。
