Rea K, Roche M, Finn D P
Department of Pharmacology and Therapeutics, National University of Ireland, Galway, Ireland.
Br J Pharmacol. 2007 Nov;152(5):633-48. doi: 10.1038/sj.bjp.0707440. Epub 2007 Sep 10.
Recent physiological, pharmacological and anatomical studies provide evidence that one of the main roles of the endocannabinoid system in the brain is the regulation of gamma-aminobutyric acid (GABA) and glutamate release. This article aims to review this evidence in the context of its implications for pain. We first provide a brief overview of supraspinal regulation of nociception, followed by a review of the evidence that the brain's endocannabinoid system modulates nociception. We look in detail at regulation of supraspinal GABAergic and glutamatergic neurons by the endocannabinoid system and by exogenously administered cannabinoids. Finally, we review the evidence that cannabinoid-mediated modulation of pain involves modulation of GABAergic and glutamatergic neurotransmission in key brain regions.
最近的生理学、药理学和解剖学研究表明，内源性大麻素系统在大脑中的主要作用之一是调节γ-氨基丁酸（GABA）和谷氨酸的释放。本文旨在结合其对疼痛的影响来综述这一证据。我们首先简要概述伤害性感受的脊髓上调节，随后综述大脑内源性大麻素系统调节伤害性感受的证据。我们详细探讨内源性大麻素系统和外源性给予的大麻素对脊髓上GABA能和谷氨酸能神经元的调节。最后，我们综述大麻素介导的疼痛调节涉及关键脑区GABA能和谷氨酸能神经传递调节的证据。
