Gladman D D
Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada.
Reumatismo. 2007;59 Suppl 1:85-7.
Psoriatic arthritis is now recognized as a potentially serious and disabling disease. Traditional therapies have not been very effective in controlling signs and symptoms or preventing progression of damage. Based on the pathogenesis of the disease new therapies have been introduced, particularly anti-TNF agents and anti-T cell agents. Several of those have shown excellent responses in clinical variables, health related quality of life and function, and in preventing radiological progression. However, not all patients have responded, and the long-term safety of these drugs remains unknown.
银屑病关节炎现已被公认为一种潜在的严重致残性疾病。传统疗法在控制症状体征或预防损害进展方面效果不佳。基于该疾病的发病机制，已引入了新的疗法，尤其是抗TNF药物和抗T细胞药物。其中几种药物在临床指标、健康相关生活质量和功能以及预防放射学进展方面均显示出良好疗效。然而，并非所有患者都有反应，且这些药物的长期安全性仍不明确。
