Biologic therapy of psoriatic arthritis.

Psoriatic arthritis is now recognized as a potentially serious and disabling disease. Traditional therapies have not been very effective in controlling signs and symptoms or preventing progression of damage. Based on the pathogenesis of the disease new therapies have been introduced, particularly anti-TNF agents and anti-T cell agents. Several of those have shown excellent responses in clinical variables, health related quality of life and function, and in preventing radiological progression. However, not all patients have responded, and the long-term safety of these drugs remains unknown.